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Polynucleotides are injectable compounds derived from DNA, used in aesthetics to support skin repair and collagen production. Here, Dr Prasad delves into the science behind them and looks at what they can and cannot do for skin rejuvenation.
First The Science Bit …
Polynucleotides, also known as PDRN (polydeoxyribonucleotide), are high-molecular-weight compounds derived from DNA responsibly sourced from salmon. They are rich in nucleotides, which play a vital role in stimulating cell growth, repairing damaged tissues and boosting collagen. Because of this, they are used in aesthetic medicine and skincare for their regenerative properties:
A Natural Boost For Healing: Polynucleotides stimulate the body’s natural regenerative processes by promoting cell growth and repair. When it comes to wound healing, cell regeneration is a key factor, and polynucleotides play a part in this. Their anti-inflammatory effect is useful in tissue healing and recovery.
Rebuilding The Foundation Of Youthful Skin: One of the key aspects of younger-looking skin is the presence of collagen and elastin, which contribute to elasticity and firmness. Polynucleotides stimulate the synthesis of both, which can soften the appearance of wrinkles and fine lines.
Oxygenation And Nutrient Boost: Polynucleotides enhance blood flow to a specific treatment area, which delivers oxygen and nutrients to the skin. This can revitalise the complexion and support recovery after treatment.
Benefits Of Polynucleotides In Aesthetics
What The Studies Show: Clinical studies report improvements in skin texture, elasticity and hydration. For instance, a study published in the Journal of Drugs in Dermatology found that PDRN treatment resulted in increased collagen and hyaluronic acid production, culminating in a smoother, more youthful complexion.
An Option For Atrophic Scars: Polynucleotides have been shown to help reduce the appearance of scars, particularly atrophic scars, the depressions in the skin caused by acne. They showed an improvement in skin texture, which is encouraging for anyone dealing with acne scarring.
Thicker, Fuller Locks: While polynucleotides are best known for their skin benefits, their potential in hair restoration should not be overlooked. Research published in the Journal of Dermatological Treatment highlights that they can stimulate follicles, potentially leading to hair thickening and regrowth.
A Brighter Complexion: Polynucleotides have been explored for their benefits when it comes to tackling hyperpigmentation. A study in the Journal of Cosmetic Dermatology reported a decrease in pigmentation and an increase in skin brightness following treatment.
The Anti-Ageing Option: Aesthetic treatments using polynucleotides have been found to improve skin elasticity and reduce the appearance of wrinkles, offering a non-surgical option that sits alongside dermal fillers and other injectables. In those studies, patients reported anti-ageing benefits with minimal side effects.
However, it is important to point out that while polynucleotides offer a promising range of benefits, you should speak to a qualified professional before starting. The procedure is minimally invasive and generally well tolerated, but, as with any medical treatment, individual reactions vary. Potential side effects and achievable results should always be discussed beforehand.
Dr Prasad xx
